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KMID : 0358820100370010012
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Journal of Korean Society of Plastic and Reconstructive Surgeons
2010 Volume.37 No. 1 p.12 ~ p.21
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The Anti-Inflammatory Effect of Pegmatite by in Vivo and in Vitro Study
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Lee Min-Hyuk
Kim Seok-Kwun
Kwon Yong-Seok
Lee Jang-Ho
Lee Keun-Cheol
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Abstract
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Purpose: This work aimed to elucidate the anti-inflammatory effect of pegmatite in vitro and in vivo.
Methods: Author evaluated the suppressive effects of pegmatite on lipopolysaccharide(LPS)-stimulated nitric oxide(NO) production, TNF-α and IL-6 release in the RAW 264.7 murine macrophages.
Results: Treatment of RAW 264.7 cells with pegmatite significantly reduced LPS-stimulated NO production and inflammatory cytokine such as TNF-α and IL-6 secretion in a concentration-dependent manner. Also pegmatite showed topical anti-inflammatory activity in the arachidonic acid(AA)-induced ear edema and acetic acid-induced increase in capillary permeability assessment in mice. It was also found that pegmatite(10mg per ear in DW) inhibited arachidonic acid induced edema at 24 h more profoundly than 1h by topical application. Furthermore, the vascular permeability increase induced by acetic acid was significantly reduced in mice that received pegmatite in 50mg per mouse.
Conclusion: Therefore the results of the present study suggest that pegmatite is a potent inhibitor of the LPS- induced NO and inflammatory cytokine in RAW 264.7 macrophages and showed anti-inflammatory activities in vivo animal model.
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KEYWORD
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Pegmatite, Anti-inflammatory activity, Ear edema, Vascular permeability, NO, LOX
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